弱监督的对象检测（WSOD）是一项任务，可使用仅在图像级注释上训练的模型来检测图像中的对象。当前的最新模型受益于自我监督的实例级别的监督，但是由于弱监督不包括计数或位置信息，因此最常见的``Argmax''标签方法通常忽略了许多对象实例。为了减轻此问题，我们提出了一种新颖的多个实例标记方法，称为对象发现。我们进一步在弱监督下引入了新的对比损失，在该监督下，没有实例级信息可用于采样，称为弱监督对比损失（WSCL）。WSCL旨在通过利用一致的功能来嵌入同一类中的向量来构建对象发现的可靠相似性阈值。结果，我们在2014年和2017年MS-Coco以及Pascal VOC 2012上取得了新的最新结果，并在Pascal VOC 2007上取得了竞争成果。

我们提出了一种新方法，用于近似于基于假设标记的候选数据点进行重新培训的主动学习获取策略。尽管这通常与深层网络不可行，但我们使用神经切线内核来近似重新进行重新培训的结果，并证明该近似值即使在主动学习设置中也无效 - 近似于“ look-aead abead”选择标准，所需的计算要少得多。 。这也使我们能够进行顺序的主动学习，即在流态中更新模型，而无需在添加每个新数据点后使用SGD重新训练模型。此外，我们的查询策略可以更好地理解模型的预测将如何通过与标准（“近视”）标准相比，通过大幅度击败其他查看策略，并获得相等或更好的性能，并取得了相等或更好的性能。基于池的主动学习中的几个基准数据集上的最新方法。

Artificial Intelligence (AI) has become commonplace to solve routine everyday tasks. Because of the exponential growth in medical imaging data volume and complexity, the workload on radiologists is steadily increasing. We project that the gap between the number of imaging exams and the number of expert radiologist readers required to cover this increase will continue to expand, consequently introducing a demand for AI-based tools that improve the efficiency with which radiologists can comfortably interpret these exams. AI has been shown to improve efficiency in medical-image generation, processing, and interpretation, and a variety of such AI models have been developed across research labs worldwide. However, very few of these, if any, find their way into routine clinical use, a discrepancy that reflects the divide between AI research and successful AI translation. To address the barrier to clinical deployment, we have formed MONAI Consortium, an open-source community which is building standards for AI deployment in healthcare institutions, and developing tools and infrastructure to facilitate their implementation. This report represents several years of weekly discussions and hands-on problem solving experience by groups of industry experts and clinicians in the MONAI Consortium. We identify barriers between AI-model development in research labs and subsequent clinical deployment and propose solutions. Our report provides guidance on processes which take an imaging AI model from development to clinical implementation in a healthcare institution. We discuss various AI integration points in a clinical Radiology workflow. We also present a taxonomy of Radiology AI use-cases. Through this report, we intend to educate the stakeholders in healthcare and AI (AI researchers, radiologists, imaging informaticists, and regulators) about cross-disciplinary challenges and possible solutions.

Deep neural networks have been successfully adopted to diverse domains including pathology classification based on medical images. However, large-scale and high-quality data to train powerful neural networks are rare in the medical domain as the labeling must be done by qualified experts. Researchers recently tackled this problem with some success by taking advantage of models pre-trained on large-scale general domain data. Specifically, researchers took contrastive image-text encoders (e.g., CLIP) and fine-tuned it with chest X-ray images and paired reports to perform zero-shot pathology classification, thus completely removing the need for pathology-annotated images to train a classification model. Existing studies, however, fine-tuned the pre-trained model with the same contrastive learning objective, and failed to exploit the multi-labeled nature of medical image-report pairs. In this paper, we propose a new fine-tuning strategy based on sentence sampling and positive-pair loss relaxation for improving the downstream zero-shot pathology classification performance, which can be applied to any pre-trained contrastive image-text encoders. Our method consistently showed dramatically improved zero-shot pathology classification performance on four different chest X-ray datasets and 3 different pre-trained models (5.77% average AUROC increase). In particular, fine-tuning CLIP with our method showed much comparable or marginally outperformed to board-certified radiologists (0.619 vs 0.625 in F1 score and 0.530 vs 0.544 in MCC) in zero-shot classification of five prominent diseases from the CheXpert dataset.

Variational autoencoders (VAEs) are powerful tools for learning latent representations of data used in a wide range of applications. In practice, VAEs usually require multiple training rounds to choose the amount of information the latent variable should retain. This trade-off between the reconstruction error (distortion) and the KL divergence (rate) is typically parameterized by a hyperparameter $\beta$. In this paper, we introduce Multi-Rate VAE (MR-VAE), a computationally efficient framework for learning optimal parameters corresponding to various $\beta$ in a single training run. The key idea is to explicitly formulate a response function that maps $\beta$ to the optimal parameters using hypernetworks. MR-VAEs construct a compact response hypernetwork where the pre-activations are conditionally gated based on $\beta$. We justify the proposed architecture by analyzing linear VAEs and showing that it can represent response functions exactly for linear VAEs. With the learned hypernetwork, MR-VAEs can construct the rate-distortion curve without additional training and can be deployed with significantly less hyperparameter tuning. Empirically, our approach is competitive and often exceeds the performance of multiple $\beta$-VAEs training with minimal computation and memory overheads.

We explore the impact of environmental conditions on the competency of machine learning agents and how real-time competency assessments improve the reliability of ML agents. We learn a representation of conditions which impact the strategies and performance of the ML agent enabling determination of actions the agent can make to maintain operator expectations in the case of a convolutional neural network that leverages visual imagery to aid in the obstacle avoidance task of a simulated self-driving vehicle.

Process mining is a methodology for the derivation and analysis of process models based on the event log. When process mining is employed to analyze business processes, the process discovery step, the conformance checking step, and the enhancements step are repeated. If a user wants to analyze a process from multiple perspectives (such as activity perspectives, originator perspectives, and time perspectives), the above procedure, inconveniently, has to be repeated over and over again. Although past studies involving process mining have applied detailed stepwise methodologies, no attempt has been made to incorporate and optimize multi-perspective process mining procedures. This paper contributes to developing a solution approach to this problem. First, we propose an automatic discovery framework of a multi-perspective process model based on deep Q-Learning. Our Dual Experience Replay with Experience Distribution (DERED) approach can automatically perform process model discovery steps, conformance check steps, and enhancements steps. Second, we propose a new method that further optimizes the experience replay (ER) method, one of the key algorithms of deep Q-learning, to improve the learning performance of reinforcement learning agents. Finally, we validate our approach using six real-world event datasets collected in port logistics, steel manufacturing, finance, IT, and government administration. We show that our DERED approach can provide users with multi-perspective, high-quality process models that can be employed more conveniently for multi-perspective process mining.

The time-series forecasting (TSF) problem is a traditional problem in the field of artificial intelligence. Models such as Recurrent Neural Network (RNN), Long Short Term Memory (LSTM), and GRU (Gate Recurrent Units) have contributed to improving the predictive accuracy of TSF. Furthermore, model structures have been proposed to combine time-series decomposition methods, such as seasonal-trend decomposition using Loess (STL) to ensure improved predictive accuracy. However, because this approach is learned in an independent model for each component, it cannot learn the relationships between time-series components. In this study, we propose a new neural architecture called a correlation recurrent unit (CRU) that can perform time series decomposition within a neural cell and learn correlations (autocorrelation and correlation) between each decomposition component. The proposed neural architecture was evaluated through comparative experiments with previous studies using five univariate time-series datasets and four multivariate time-series data. The results showed that long- and short-term predictive performance was improved by more than 10%. The experimental results show that the proposed CRU is an excellent method for TSF problems compared to other neural architectures.

We develop a wall model for large-eddy simulation (LES) that takes into account various pressure-gradient effects using multi-agent reinforcement learning (MARL). The model is trained using low-Reynolds-number flow over periodic hills with agents distributed on the wall along the computational grid points. The model utilizes a wall eddy-viscosity formulation as the boundary condition, which is shown to provide better predictions of the mean velocity field, rather than the typical wall-shear stress formulation. Each agent receives states based on local instantaneous flow quantities at an off-wall location, computes a reward based on the estimated wall-shear stress, and provides an action to update the wall eddy viscosity at each time step. The trained wall model is validated in wall-modeled LES (WMLES) of flow over periodic hills at higher Reynolds numbers, and the results show the effectiveness of the model on flow with pressure gradients. The analysis of the trained model indicates that the model is capable of distinguishing between the various pressure gradient regimes present in the flow.

Deep metric learning (DML) aims to automatically construct task-specific distances or similarities of data, resulting in a low-dimensional representation. Several significant metric-learning methods have been proposed. Nonetheless, no approach guarantees the preservation of the ordinal nature of the original data in a low-dimensional space. Ordinal data are ubiquitous in real-world problems, such as the severity of symptoms in biomedical cases, production quality in manufacturing, rating level in businesses, and aging level in face recognition. This study proposes a novel angular triangle distance (ATD) and ordinal triplet network (OTD) to obtain an accurate and meaningful embedding space representation for ordinal data. The ATD projects the ordinal relation of data in the angular space, whereas the OTD learns its ordinal projection. We also demonstrated that our new distance measure satisfies the distance metric properties mathematically. The proposed method was assessed using real-world data with an ordinal nature, such as biomedical, facial, and hand-gestured images. Extensive experiments have been conducted, and the results show that our proposed method not only semantically preserves the ordinal nature but is also more accurate than existing DML models. Moreover, we also demonstrate that our proposed method outperforms the state-of-the-art ordinal metric learning method.